A harmonized meta-knowledgebase of clinical interpretations of cancer genomic variants

We developed a framework for aggregating and harmonizing variant interpretations to produce a meta-knowledgebase of 12,856 aggregate interpretations covering 3,437 unique variants in 415 genes... We have developed and hosted a public web interface for exploring the VICC meta-knowledgebase, freely available online at This interface accesses an ElasticSearch index for the most recent (and continually updated) data of the VICC harmonized knowledgebase.